PUBLICATIONS
Abstract
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.
August 2021
Robynne G. Braun, MD, PhD, Laura Heitsch, MD, John W. Cole, MD, MS, Arne Lindgren, MD, PhD, Adam de Havenon, MD, Jason A. Dude, BS, Keith R. Lohse, PhD, Steve C. Cramer, MD, and Bradford B. Worrall, MD, MSc, on behalf of the GPAS Collaboration, Phenotyping Core.
April 2021
Arne Lindgren, Robynne Braun, Jennifer J Majersik, Philip Clatworthy, Shraddha Mainali, Colin P Derdeyn, Jane Margaret Maguire, Christina Jern, Jonathan Rosand, John W Cole, Jin-Moo Lee, Pooja Khatri, Paul A Nyquist, Stephanie Debette, Loo Keat Wei, Tatjana Rundek, Dana Leifer, Vincent Thijs, Robin Lemmens, Laura Heitsch, Kameshwar Prasad, Jordi Jimenez-Conde, Martin Dichgans, Natalia S Rost, Steven C Cramer, Julie Bernhardt, Bradford B Worrall, Israel Fernandez Cadenas.
Int J Stroke 2021 Apr 26
March 2021
Steven C Cramer, Steven L Wolf, Jeffrey L Saver, Karen C Johnston, J Mocco, Maarten G Lansberg, Sean I Savitz, David S Liebeskind, Wade Smith, Max Wintermark, Jordan J Elm, Pooja Khatri, Joseph P Broderick, Scott Janis, NIH StrokeNet Recovery and Rehabilitation Group and the Acute Stroke Group*
Stroke. 2021 Mar;52(3):1154-1161
June 2019
Overlap in the Genetic Architecture of Stroke Risk, Early Neurological Changes, and Cardiovascular Risk Factors
Laura Ibanez, Laura Heitsch , Umber Dube, Fabiana H G Farias, John Budde, Kristy Bergmann, Rich Davenport, Joseph Bradley, Caty Carrera, Janne Kinnunen, Hanne Sallinen, Daniel Strbian, Agnieszka Slowik, Israel Fernandez-Cadenas, Joan Montaner, Jin-Moo Lee, Carlos Cruchaga
Stroke. 2019 Jun;50(6):1339-1345
Abstract Full Text
June 2021
Adam de Havenon, David L Tirschwell, Laura Heitsch, Steven C Cramer, Robynne Braun, John Cole, Vivek Reddy, Jennifer J Majersik, Arne Lindgren, Bradford B Worrall
Neurol Clin Pract. 2021 Jun;11(3):e239-e244
April 2021
John W Cole, Taiwo Adigun, Rufus Akinyemi, Onoja Matthew Akpa, Steven Bell, Bowang Chen, Jordi Jimenez Conde, Uxue Lazcano Dobao, Israel Fernandez , Myriam Fornage, Cristina Gallego-Fabrega, Christina Jern, Michael Krawczak , Arne Lindgren, Hugh S Markus, Olle Melander, Mayowa Owolabi, Kristina Schlicht , Martin Söderholm, Vinodh Srinivasasainagendra, Carolina Soriano Tárraga, Martin Stenman, Hemant Tiwari , Margaret Corasaniti, Natalie Fecteau, Beth Guizzardi, Haley Lopez, Kevin Nguyen, Brady Gaynor, Timothy O'Connor, O Colin Stine , Steven J Kittner, Patrick McArdle, Braxton D Mitchell, Huichun Xu, Caspar Grond-Ginsbach
PloS One 2021 Apr 19
January 2021
Laura Heitsch, MD; Laura Ibanez, PhD; Caty Carrera, MD, PhD; Michael M. Binkley, PhD; Daniel Strbian, MD, PhD; Turgut Tatlisumak , MD, PhD; Alejandro Bustamante, MD, PhD; Marc Ribó, MD, PhD; Carlos Molina, MD, PhD; Antoni Dávalos, MD, PhD; Elena López-Cancio , MD, PhD; Lucia Muñoz-Narbona , PhD, RN; Carol Soriano-Tárraga, PhD; Eva Giralt-Steinhauer, MD, PhD; Victor Obach, MD; Agnieszka Slowik, MD, PhD; Joanna Pera , MD, PhD; Katarzyna Lapicka-Bodzioch, MSc; Justyna Derbisz, et al.
Stroke. 2021 Jan;52(1):132-141
Abstract Full Text